Polyethylene Glycol Omega-amino Acid

360ip partner’s invention is a novel PEG omega-amino acid structure that allows the PEG to have two ends, one amine termini and one carboxyl termini protected. The amine termini can be activated and conjugated to other chemicals under acidic conditions. The carboxyl termini can be activated and conjugated to other chemicals under alkaline conditions. This enables selective conjugation of the termini to the chemical of interest. This property also has the additional benefit of preventing the amine terminal from reacting with the carboxyl terminal.

The invention also involves a preparation method for synthesizing PEG omega-amino acid that involves a solid-phase reaction, azidation reaction and Curtius rearrangement reaction. This overcomes the complicated separation and purification in the synthesis of PEG omega-amino acid of the existing methods

The partner’s technology has the following advantages:

Moderate reaction conditions

Short synthetic route (reaction time 35-40 hours)

Simple separation and purification (column chromatography)Yield of more than 70%

Purity of ~ 95%

Materials used are less toxic as compared to epoxy ethane used in conventional PEG compounds